Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Authors Organisations
  • Coen M. Adema(Author)
    University of New Mexico
  • Ladeana W. Hillier(Author)
    Washington University in St. Louis
  • Catherine S. Jones(Author)
  • Eric S. Loker(Author)
    University of New Mexico
  • Matty Knight(Author)
    The George Washington University
    University of the District of Columbia
  • Patrick Minx(Author)
    Washington University in St. Louis
  • Guilherme Oliveira(Author)
    René Rachou Research Center
  • Nithya Raghavan(Author)
  • Andrew Shedlock(Author)
    Medical University of South Carolina College of Graduate Studies
  • Laurence Rodrigues do Amaral(Author)
    Federal University of Uberlândia
  • Halime D. Arican-Goktas(Author)
    Brunel University
  • Juliana G. Assis(Author)
    René Rachou Research Center
  • Elio Hideo Baba(Author)
    René Rachou Research Center
  • Olga L. Baron(Author)
    Institut Sophia Agrobiotech
  • Christopher J. Bayne(Author)
    Oregon State University
  • Utibe Bickham-Wright(Author)
    University of Wisconsin-Madison
  • Kyle K. Biggar(Author)
    Carleton University
  • Michael Blouin(Author)
    Oregon State University
  • Bryony C. Bonning(Author)
    Iowa State University of Science and Technology
  • Chris Botka(Author)
    Harvard Medical School (HMS)
  • Joanna M. Bridger(Author)
    Brunel University
  • Katherine M. Buckley(Author)
    University of Toronto
  • Sarah K. Buddenborg(Author)
    University of New Mexico
  • Roberta Lima Caldeira(Author)
    René Rachou Research Center
  • Julia Carleton(Author)
    Utah State University
  • Omar S. Carvalho(Author)
    René Rachou Research Center
  • Maria G. Castillo(Author)
    New Mexico State University
  • Iain Chalmers(Author)
  • Mikkel Christensens(Author)
    European Bioinformatics Institute - EMBL-EBI
  • Sandra Clifton(Author)
    Washington University in St. Louis
  • Celine Cosseau(Author)
    University Montpellier
  • Christine Coustau(Author)
    Institut Sophia Agrobiotech
  • Richard M. Cripps(Author)
    University of New Mexico
  • Yesid Cuesta-Astroz(Author)
    René Rachou Research Center
  • Scott F. Cummins(Author)
    University of the Sunshine Coast
  • Leon Di Stephano(Author)
    The Walter and Eliza Hall Institute for Medical Research
  • Nathalie Dinguirard(Author)
    University of Wisconsin-Madison
  • David Duval(Author)
    University Montpellier
  • Scott Emrich(Author)
    University of Notre Dame
  • Cédric Feschotte(Author)
    Utah State University
  • Rene Feyereisen(Author)
    University of Copenhagen
  • Peter Fitzgerald(Author)
    National Cancer Institute at Frederick
  • Catrina Fronick(Author)
    Washington University in St. Louis
  • Lucinda Fulton(Author)
    Washington University in St. Louis
  • Richard Galinier(Author)
    University Montpellier
  • Sandra G. Gava(Author)
    René Rachou Research Center
  • Michael Geusz(Author)
    Bowling Green State University
  • Kathrin K. Geyer(Author)
  • Gloria I. Giraldo-Calderón(Author)
    University of Notre Dame
  • Matheus de Souza Gomes(Author)
    Federal University of Uberlândia
  • Michelle A. Gordy(Author)
    Bowling Green State University
  • Benjamin Gourbal(Author)
    University Montpellier
  • Christoph Grunau(Author)
    University Montpellier
  • Patrick C. Hanington(Author)
    University of Alberta
  • Karl Hoffmann(Author)
  • Daniel Hughes(Author)
    European Bioinformatics Institute - EMBL-EBI
  • Judith Humphries(Author)
  • Daniel J. Jackson(Author)
    Georg-August Universität Göttingen
  • Liana K. Jannotti-Passos(Author)
    René Rachou Research Center
  • Wander De Jesus Jeremias(Author)
    René Rachou Research Center
  • Susan Jobling(Author)
    Brunel University
  • Bishoy Kamel(Author)
    University of Pennsylvania
  • Aurélie Kapusta(Author)
    Utah State University
  • Satwant Kaur(Author)
    Brunel University
  • Joris M. Koene(Author)
    Vrije Universiteit
  • Andrea B. Kohn(Author)
    University of Florida
  • Dan Lawson(Author)
    European Bioinformatics Institute - EMBL-EBI
  • Scott P Lawton(Author)
  • Di Liang(Author)
    University of the Sunshine Coast
  • Yanin Limpanont(Author)
    University of the Sunshine Coast
  • Sijun Liu(Author)
  • Anne E. Lockyer(Author)
    Brunel University
  • Tyanna L. Lovato(Author)
    University of New Mexico
  • Fernanda Ludolf(Author)
    René Rachou Research Center
  • Vince Magrini(Author)
    Washington University in St. Louis
  • Donald P. Mcmanus(Author)
    QIMR Berghofer Medical Research Institute
  • Monica Medina(Author)
    University of Pennsylvania
  • Milind Misra(Author)
    University of New Mexico
  • Guillaume Mitta(Author)
    University Montpellier
  • Gerald M. Mkoji(Author)
    Kenya Medical Research Institute
  • Michael J. Montague(Author)
    University of Pennsylvania
  • Cesar Montelongo(Author)
    New Mexico State University
  • Leonid L. Moroz(Author)
    University of Florida
  • Monica C. Munoz-Torres(Author)
    Lawrence Berkeley National Laboratory
  • Umar Niazi(Author)
  • Leslie R. Noble(Author)
  • Francislon S. Oliveira(Author)
    René Rachou Research Center
  • Fabiano S. Pais(Author)
    René Rachou Research Center
  • Anthony T. Papenfuss(Author)
    The Walter and Eliza Hall Institute for Medical Research
  • Rob Peace(Author)
    Carleton University
  • Janeth J. Pena(Author)
    University of New Mexico
  • Emmanuel A. Pila(Author)
    University of Alberta
  • Titouan Quelais(Author)
    University Montpellier
  • Brian J. Raney(Author)
    University of California, Santa Cruz
  • Jonathan P. Rast(Author)
    University of Toronto
  • David Rollinson(Author)
    British Natural History Museum
  • Izinara C. Rosse(Author)
    René Rachou Research Center
  • Bronwyn Rotgans(Author)
    University of the Sunshine Coast
  • Edwin J. Routledge(Author)
    Brunel University
  • Kathryn M. Ryan(Author)
    University of New Mexico
  • Larissa L. S. Scholte(Author)
    René Rachou Research Center
  • Kenneth B. Storey(Author)
    Carleton University
  • Martin Swain(Author)
  • Jacob A. Tennessen(Author)
    Oregon State University
  • Chad Tomlinson(Author)
    Washington University in St. Louis
  • Damian L. Trujillo(Author)
    University of New Mexico
  • Emanuela V. Volpi(Author)
    University of Westminster
  • Anthony J. Walker(Author)
    Kingston University
  • Tianfang Wang(Author)
    University of the Sunshine Coast
  • Ittiprasert Wannaporn(Author)
    The George Washington University
  • Wesley C. Warren(Author)
    Washington University in St. Louis
  • Xiao-Jun Wu(Author)
    University of Wisconsin-Madison
  • Timothy P. Yoshino(Author)
    University of Wisconsin-Madison
  • Mohammed Yusuf(Author)
    University College London
  • Si-Ming Zhang(Author)
    University of New Mexico
  • Min Zhao(Author)
    University of the Sunshine Coast
  • Richard K. Wilson(Author)
    Washington University in St. Louis
Type Article
Original languageEnglish
Article number15451 (2017)
Pages (from-to)15451
JournalNature Communications
Volume8
Early online date16 May 2017
DOI
Publication statusE-pub ahead of print - 16 May 2017
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Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

Keywords

  • DNA sequencing, Genome, Genome informatics, Zoology