Transgenic plants as factories for biopharmaceuticals

Authors Organisations
Type Article
Original languageEnglish
Pages (from-to)1151-1155
JournalNature Biotechnology
Volume18
DOI
Publication statusPublished - 2000
Links
Permanent link
View graph of relations
Citation formats

Abstract

biopharmaceutical proteins and peptides because they are easily transformed and provide a cheap source of protein. Several biotechnology companies are now actively developing, field testing, and patenting plant expression systems, while clinical trials are proceeding on the first biopharmaceuticals derived from them. One transgenic plant-derived biopharmaceutical, hirudin, is now being commercially produced in Canada for the first time. Product purification is potentially an expensive process, and various methods are currently being developed to overcome this problem, including oleosin-fusion technology, which allows extraction with oil bodies. In some cases, delivery of a biopharmaceutical product by direct ingestion of the modified plant potentially removes the need for purification. Such biopharmaceuticals and edible vaccines can be stored and distributed as seeds, tubers, or fruits, making immunization programs in developing countries cheaper and potentially easier to administer. Some of the most expensive biopharmaceuticals of restricted availability, such as glucocerebrosidase, could become much cheaper and more plentiful through production in transgenic plants.

Keywords

  • biopharmaceuticals, GM crops, edible vaccine, antibodies, production systems