The hypersensitive response; the centenary is upon us but how much do we know?

TY - JOUR

T1 - The hypersensitive response; the centenary is upon us but how much do we know?

AU - Mur, Luis A. J.

AU - Kenton, Paul

AU - Lloyd, Amanda J.

AU - Ougham, Helen J.

AU - Prats, Elena

N1 - Mur, L. A., Kenton, P., Lloyd, A. J., Ougham, H. J., Prats, E. (2008). The hypersensitive response: the centenary is upon us but how much do we know?  Journal of Experimental Botany, 59, (3), 501-520. Modelling Plant Systems. SEB Annual meeting, Glasgow, UK, 28-29 June 2007. Sponsorship: BBSRC: Royal Society : Aberystwyth University Research Fund: EU Human Resources Mobility Fund: ERG : Spanish Science and Technology Ministry. On file IMPF: 04.00 RONO: 1310 3001

PY - 2007/12/12

Y1 - 2007/12/12

N2 - With the centenary of the first descriptions of ‘hypersensitiveness’ following pathogenic challenge upon us, it is appropriate to assess our current understanding of the hypersensitive response (HR) form of cell death. In recent decades our understanding of the initiation, associated signalling, and some important proteolytic events linked to the HR has dramatically increased. Genetic approaches are increasingly elucidating the function of the HR initiating resistance genes and there have been extensive analyses of death-associated signals, calcium, reactive oxygen species (ROS), nitric oxide, salicylic acid, and now sphingolipids. At the same time, attempts to draw parallels between mammalian apoptosis and the HR have been largely unsuccessful and it may be better to consider the HR to be a distinctive form of plant cell death. We will consider if the HR form of cell death may occur through metabolic dysfunction in which malfunctioning organelles may play a major role. This review will highlight that although our knowledge of parts of the HR is excellent, a comprehensive molecular model is still to be attained.

AB - With the centenary of the first descriptions of ‘hypersensitiveness’ following pathogenic challenge upon us, it is appropriate to assess our current understanding of the hypersensitive response (HR) form of cell death. In recent decades our understanding of the initiation, associated signalling, and some important proteolytic events linked to the HR has dramatically increased. Genetic approaches are increasingly elucidating the function of the HR initiating resistance genes and there have been extensive analyses of death-associated signals, calcium, reactive oxygen species (ROS), nitric oxide, salicylic acid, and now sphingolipids. At the same time, attempts to draw parallels between mammalian apoptosis and the HR have been largely unsuccessful and it may be better to consider the HR to be a distinctive form of plant cell death. We will consider if the HR form of cell death may occur through metabolic dysfunction in which malfunctioning organelles may play a major role. This review will highlight that although our knowledge of parts of the HR is excellent, a comprehensive molecular model is still to be attained.

KW - pathogen

KW - hypersensitive response

KW - programmed cell death

KW - resistance

U2 - 10.1093/jxb/erm239

DO - 10.1093/jxb/erm239

M3 - Article

VL - 59

SP - 501

EP - 520

JO - Journal of Experimental Botany

JF - Journal of Experimental Botany

SN - 0022-0957

IS - 3

ER -