The Free-movement pattern Y-mazeA cross-species measure of working memory and executive function

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The Free-movement pattern Y-maze : A cross-species measure of working memory and executive function. / Cleal, Madeleine; Fontana, Barbara D.; Ranson, Daniel C.; McBride, Sebastian D.; Swinny, Jerome D.; Redhead, Edward S.; Parker, Matthew O.

In: Behavior Research Methods, 03.08.2020.

Research output: Contribution to journalArticle

Harvard

Cleal, M, Fontana, BD, Ranson, DC, McBride, SD, Swinny, JD, Redhead, ES & Parker, MO 2020, 'The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function', Behavior Research Methods. https://doi.org/10.3758/s13428-020-01452-x

APA

Cleal, M., Fontana, B. D., Ranson, D. C., McBride, S. D., Swinny, J. D., Redhead, E. S., & Parker, M. O. (2020). The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function. Behavior Research Methods. https://doi.org/10.3758/s13428-020-01452-x

Vancouver

Cleal M, Fontana BD, Ranson DC, McBride SD, Swinny JD, Redhead ES et al. The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function. Behavior Research Methods. 2020 Aug 3. https://doi.org/10.3758/s13428-020-01452-x

Author

Cleal, Madeleine ; Fontana, Barbara D. ; Ranson, Daniel C. ; McBride, Sebastian D. ; Swinny, Jerome D. ; Redhead, Edward S. ; Parker, Matthew O. / The Free-movement pattern Y-maze : A cross-species measure of working memory and executive function. In: Behavior Research Methods. 2020.

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@article{aaf8c341c0a94d878d88a82fb9083868,
title = "The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function",
abstract = "Numerous neurodegenerative and psychiatric disorders are associated with deficits in executive functions such as working memory and cognitive flexibility. Progress in developing effective treatments for disorders may benefit from targeting these cognitive impairments, the success of which is predicated on the development of animal models with validated behavioural assays. Zebrafish offer a promising model for studying complex brain disorders, but tasks assessing executive function are lacking. The Free-movement pattern (FMP) Y-maze combines aspects of the common Y-maze assay, which exploits the inherent motivation of an organism to explore an unknown environment, with analysis based on a series of sequential two-choice discriminations. We validate the task as a measure of working memory and executive function by comparing task performance parameters in adult zebrafish treated with a range of glutamatergic, cholinergic and dopaminergic drugs known to impair working memory and cognitive flexibility. We demonstrate the cross-species validity of the task by assessing performance parameters in adapted versions of the task for mice and Drosophila, and finally a virtual version in humans, and identify remarkable commonalities between vertebrate species{\textquoteright} navigation of the maze. Together, our results demonstrate that the FMP Y-maze is a sensitive assay for assessing working memory and cognitive flexibility across species from invertebrates to humans, providing a simple and widely applicable behavioural assay with exceptional translational relevance.",
keywords = "Drosophila, Executive function, FMP Y-maze, Translational research, Working memory, Zebrafish",
author = "Madeleine Cleal and Fontana, {Barbara D.} and Ranson, {Daniel C.} and McBride, {Sebastian D.} and Swinny, {Jerome D.} and Redhead, {Edward S.} and Parker, {Matthew O.}",
year = "2020",
month = aug,
day = "3",
doi = "10.3758/s13428-020-01452-x",
language = "English",
journal = "Behavior Research Methods",
issn = "1554-351X",
publisher = "Springer Nature",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - The Free-movement pattern Y-maze

T2 - A cross-species measure of working memory and executive function

AU - Cleal, Madeleine

AU - Fontana, Barbara D.

AU - Ranson, Daniel C.

AU - McBride, Sebastian D.

AU - Swinny, Jerome D.

AU - Redhead, Edward S.

AU - Parker, Matthew O.

PY - 2020/8/3

Y1 - 2020/8/3

N2 - Numerous neurodegenerative and psychiatric disorders are associated with deficits in executive functions such as working memory and cognitive flexibility. Progress in developing effective treatments for disorders may benefit from targeting these cognitive impairments, the success of which is predicated on the development of animal models with validated behavioural assays. Zebrafish offer a promising model for studying complex brain disorders, but tasks assessing executive function are lacking. The Free-movement pattern (FMP) Y-maze combines aspects of the common Y-maze assay, which exploits the inherent motivation of an organism to explore an unknown environment, with analysis based on a series of sequential two-choice discriminations. We validate the task as a measure of working memory and executive function by comparing task performance parameters in adult zebrafish treated with a range of glutamatergic, cholinergic and dopaminergic drugs known to impair working memory and cognitive flexibility. We demonstrate the cross-species validity of the task by assessing performance parameters in adapted versions of the task for mice and Drosophila, and finally a virtual version in humans, and identify remarkable commonalities between vertebrate species’ navigation of the maze. Together, our results demonstrate that the FMP Y-maze is a sensitive assay for assessing working memory and cognitive flexibility across species from invertebrates to humans, providing a simple and widely applicable behavioural assay with exceptional translational relevance.

AB - Numerous neurodegenerative and psychiatric disorders are associated with deficits in executive functions such as working memory and cognitive flexibility. Progress in developing effective treatments for disorders may benefit from targeting these cognitive impairments, the success of which is predicated on the development of animal models with validated behavioural assays. Zebrafish offer a promising model for studying complex brain disorders, but tasks assessing executive function are lacking. The Free-movement pattern (FMP) Y-maze combines aspects of the common Y-maze assay, which exploits the inherent motivation of an organism to explore an unknown environment, with analysis based on a series of sequential two-choice discriminations. We validate the task as a measure of working memory and executive function by comparing task performance parameters in adult zebrafish treated with a range of glutamatergic, cholinergic and dopaminergic drugs known to impair working memory and cognitive flexibility. We demonstrate the cross-species validity of the task by assessing performance parameters in adapted versions of the task for mice and Drosophila, and finally a virtual version in humans, and identify remarkable commonalities between vertebrate species’ navigation of the maze. Together, our results demonstrate that the FMP Y-maze is a sensitive assay for assessing working memory and cognitive flexibility across species from invertebrates to humans, providing a simple and widely applicable behavioural assay with exceptional translational relevance.

KW - Drosophila

KW - Executive function

KW - FMP Y-maze

KW - Translational research

KW - Working memory

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=85088992879&partnerID=8YFLogxK

U2 - 10.3758/s13428-020-01452-x

DO - 10.3758/s13428-020-01452-x

M3 - Article

C2 - 32748238

AN - SCOPUS:85088992879

JO - Behavior Research Methods

JF - Behavior Research Methods

SN - 1554-351X

ER -

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