Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

Authors Organisations
  • Sarfaraz Ahmed(Author)
    King Saud University
  • Mohammad Nur-e-Alam(Author)
    King Saud University
  • Ifat Shah(Author)
  • Simon J. Coles(Author)
    University of Southampton
  • Rahman M. Hafizur(Author)
    University of Karachi
  • Abdul Hameed(Author)
    University of Karachi
  • James B. Orton(Author)
    University of Southampton
  • Michael D. Threadgill(Author)
    University of Bath
  • Muhammad Yousaf(Author)
    King Saud University
  • Abdulaziz M. Alqahtani(Author)
    King Saud University
  • Adnan J. Al-Rehaily(Author)
    King Saud University
Type Article
Original languageEnglish
Article number112213
JournalPhytochemistry
Volume170
Early online date28 Nov 2019
DOI
Publication statusE-pub ahead of print - 28 Nov 2019
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Abstract

Clutia lanceolata Forssk. (C. lanceolata) is a medicinal plant native to sub-Saharan Africa and the Arabian Peninsula. Phytochemical investigation of the aerial parts of C. lanceolata yielded twenty-one coumarins including methylthio and methylsulfinyl-coumarins. Thirteen of these compounds are reported here for the first time, named as cluteolin A to M. The remaining eight compounds are known but have not been associated previously with C. lanceolata. The structures of the undescribed compounds were elucidated from their 2D NMR and MS spectra. Single crystal X-ray analyses confirmed the structures of eleven compounds. As, in Saudi Arabian tradition, C. lanceolata has been reported to have anti-diabetic and anti-fungal properties, the coumarins were examined for their biological activity. Seven compounds strongly enhanced the glucose-triggered release of insulin by murine pancreatic islets, with two compounds showing more than two-fold enhancement of insulin secretion, compared with the standard drug glimepiride.

Keywords

  • Clutia lanceolata Forssk, peraceae, coumarins, methylthiocoumarins, single x-ray crystallography, Murine islets, insulin

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  • Stimulation of insulin secretion by 5-methulcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk

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