Schistosoma mansoni venom allergen-like proteinsphylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Authors Organisations
Type Article
Original languageEnglish
JournalInternational Journal for Parasitology
Early online date25 May 2019
DOI
Publication statusPublished - 01 Jul 2019
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Abstract

Schistosoma mansoni venom allergen-like proteins (SmVALs) are part of a diverse protein superfamily partitioned into two groups (group 1 and group 2). Phylogenetic analyses of group 1 SmVALs revealed that members could be segregated into subclades (A-D); these subclades share similar gene expression patterns across the parasite lifecycle and immunological cross-reactivity. Furthermore, whole-mount in situ hybridization demonstrated that the phylogenetically, transcriptionally and immunologically-related SmVAL4, 10, 18 and 19 (subclade C) were all localized to the pre-acetabular glands of immature cercariae. Our results suggest that SmVAL group 1 phylogenetic relationships, stage-specific transcriptional profiles and tissue localization are predictive of immunological cross-reactivity.

Keywords

  • venom allergen-like, immunological cross reactivity, tissue localisation, schistosoma mansoni