PerspectiveDietary Biomarkers of Intake and Exposure - Exploration with Omics Approaches

Authors Organisations
  • Padma Maruvada(Author)
    National Institutes of Health
  • Johanna W. Lampe(Author)
    Fred Hutchinson Cancer Research Center
  • David S. Wishart(Author)
    University of Alberta
  • Dinesh Barupal(Author)
    University of California, Davis
  • Deirdra N. Chester(Author)
    USDA Institute of Food Safety and Nutrition at the National Institute of Food and Agriculture
  • Dylan Dodd(Author)
    Stanford University
  • Yannick Djoumbou-Feunang(Author)
    University of Alberta
  • Pieter C. Dorrestein(Author)
    University of California, San Diego
  • Lars O. Dragsted(Author)
    University of Copenhagen
  • John Draper(Author)
  • Linda C. Duffy(Author)
    National Institutes of Health
  • Johanna T. Dwyer(Author)
    National Institutes of Health
  • Nancy J. Emenaker(Author)
    National Institutes of Health
  • Oliver Fiehn(Author)
    University of California, Davis
  • Robert E. Gerszten(Author)
    Harvard Medical School (HMS)
  • Frank B. Hu(Author)
    Harvard TH Chan School of Public Health
    Brigham and Women's Hospital and Harvard Medical School
  • Robert W. Karp(Author)
    National Institutes of Health
  • David M. Klurfeld(Author)
    United States Department of Agriculture
  • Maren R. Laughlin(Author)
    National Institutes of Health
  • A. Roger Little(Author)
    National Institutes of Health
  • Christopher J. Lynch(Author)
    National Institutes of Health
  • Steven C. Moore(Author)
    National Institutes of Health
  • Holly L. Nicastro(Author)
    National Institutes of Health
  • Diane M. O'Brien(Author)
    University of Alaska-Fairbanks
  • José M. Ordovás(Author)
    Tufts University
  • Stavroula K. Osganian(Author)
    National Institutes of Health
  • Mary Playdon(Author)
    University of Utah
  • Ross Prentice(Author)
    Fred Hutchinson Cancer Research Center
  • Daniel Raftery(Author)
    Fred Hutchinson Cancer Research Center
  • Nichole Reisdorph(Author)
    University of Colorado
  • Helen M. Roche(Author)
    University College Dublin
  • Sharon A. Ross(Author)
    National Institutes of Health
  • Shengmin Sang(Author)
    North Carolina A&T State University
  • Augustin Scalbert(Author)
    International Agency for Research on Cancer
  • Pothur R. Srinivas(Author)
    National Institutes of Health
  • Steven H. Zeisel(Author)
    University of North Carolina at Chapel Hill
Type Article
Original languageEnglish
Article numbernmz075
JournalAdvances in Nutrition
Publication statusPublished - 06 Aug 2019
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While conventional nutrition research has yielded biomarkers such as doubly labeled water for energy metabolism and 24-h urinary nitrogen for protein intake, a critical need exists for additional, equally robust biomarkers that allow for objective assessment of specific food intake and dietary exposure. Recent advances in high-throughput MS combined with improved metabolomics techniques and bioinformatic tools provide new opportunities for dietary biomarker development. In September 2018, the NIH organized a 2-d workshop to engage nutrition and omics researchers and explore the potential of multiomics approaches in nutritional biomarker research. The current Perspective summarizes key gaps and challenges identified, as well as the recommendations from the workshop that could serve as a guide for scientists interested in dietary biomarkers research. Topics addressed included study designs for biomarker development, analytical and bioinformatic considerations, and integration of dietary biomarkers with other omics techniques. Several clear needs were identified, including larger controlled feeding studies, testing a variety of foods and dietary patterns across diverse populations, improved reporting standards to support study replication, more chemical standards covering a broader range of food constituents and human metabolites, standardized approaches for biomarker validation, comprehensive and accessible food composition databases, a common ontology for dietary biomarker literature, and methodologic work on statistical procedures for intake biomarker discovery. Multidisciplinary research teams with appropriate expertise are critical to moving forward the field of dietary biomarkers and producing robust, reproducible biomarkers that can be used in public health and clinical research


  • dietary biomarkers, dietary intervention studies, diet, nutrition, metabolomics