PCRPi-DBa database of computationally annotated hot spots in protein interfaces

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PCRPi-DB : a database of computationally annotated hot spots in protein interfaces. / Segura, Joan; Fernandez-Fuentes, Narcis.

In: Nucleic Acids Research, Vol. 39, No. Database issue, 2011, p. D755-60.

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Segura, Joan ; Fernandez-Fuentes, Narcis. / PCRPi-DB : a database of computationally annotated hot spots in protein interfaces. In: Nucleic Acids Research. 2011 ; Vol. 39, No. Database issue. pp. D755-60.

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@article{3de85cda381d4d4494b7965a2b4b01ad,
title = "PCRPi-DB: a database of computationally annotated hot spots in protein interfaces",
abstract = "Protein-protein interactions are central to almost any cellular process. Although typically protein interfaces are large, it is well established that only a relatively small region, the so-called 'hot spot', contributes the most to the total binding energy. There is a clear interest in identifying hot spots because of its application in drug discovery and protein design. Presaging Critical Residues in Protein Interfaces Database (PCRPi-DB) is a public repository that archives computationally annotated hot spots in protein complexes for which the 3D structure is known. Hot spots have been annotated using a new and highly accurate computational method developed in the lab. PCRPi-DB is freely available to the scientific community at http://www.bioinsilico.org/PCRPIDB. Besides browsing and querying the contents of the database, extensive documentation and links to relevant on-line resources and contents are available to users. PCRPi-DB is updated on a weekly basis.",
author = "Joan Segura and Narcis Fernandez-Fuentes",
year = "2011",
doi = "10.1093/nar/gkq1068",
language = "English",
volume = "39",
pages = "D755--60",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "Database issue",

}

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TY - JOUR

T1 - PCRPi-DB

T2 - a database of computationally annotated hot spots in protein interfaces

AU - Segura, Joan

AU - Fernandez-Fuentes, Narcis

PY - 2011

Y1 - 2011

N2 - Protein-protein interactions are central to almost any cellular process. Although typically protein interfaces are large, it is well established that only a relatively small region, the so-called 'hot spot', contributes the most to the total binding energy. There is a clear interest in identifying hot spots because of its application in drug discovery and protein design. Presaging Critical Residues in Protein Interfaces Database (PCRPi-DB) is a public repository that archives computationally annotated hot spots in protein complexes for which the 3D structure is known. Hot spots have been annotated using a new and highly accurate computational method developed in the lab. PCRPi-DB is freely available to the scientific community at http://www.bioinsilico.org/PCRPIDB. Besides browsing and querying the contents of the database, extensive documentation and links to relevant on-line resources and contents are available to users. PCRPi-DB is updated on a weekly basis.

AB - Protein-protein interactions are central to almost any cellular process. Although typically protein interfaces are large, it is well established that only a relatively small region, the so-called 'hot spot', contributes the most to the total binding energy. There is a clear interest in identifying hot spots because of its application in drug discovery and protein design. Presaging Critical Residues in Protein Interfaces Database (PCRPi-DB) is a public repository that archives computationally annotated hot spots in protein complexes for which the 3D structure is known. Hot spots have been annotated using a new and highly accurate computational method developed in the lab. PCRPi-DB is freely available to the scientific community at http://www.bioinsilico.org/PCRPIDB. Besides browsing and querying the contents of the database, extensive documentation and links to relevant on-line resources and contents are available to users. PCRPi-DB is updated on a weekly basis.

UR - http://hdl.handle.net/2160/8990

U2 - 10.1093/nar/gkq1068

DO - 10.1093/nar/gkq1068

M3 - Article

C2 - 21097468

VL - 39

SP - D755-60

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - Database issue

ER -

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