Nutrition and frailtyOpportunities for prevention and treatment

Authors Organisations
  • Mary Ni Lochlainn(Author)
    King's College London
    St. Thomas' Hospital, London
  • Natalie J. Cox(Author)
    University of Southampton
    University Hospital Southampton NHS Foundation Trust
  • Thomas Wilson(Author)
  • Richard P. G. Hayhoe(Author)
    University of East Anglia
    Anglia Ruskin University
  • Sheena E. Ramsay(Author)
    Newcastle University
  • Antoneta Granic(Author)
    Newcastle University
    Newcastle upon Tyne Hospitals NHS Foundation Trust
  • Masoud Isanejad(Author)
    University of Liverpool
  • Helen C. Roberts(Author)
    University of Southampton
    University Hospital Southampton NHS Foundation Trust
  • Daisy Wilson(Author)
    University of Birmingham
  • Carly Welch(Author)
    University of Birmingham
    University of Nottingham
  • Christopher Hurst(Author)
    Newcastle University
    Newcastle upon Tyne Hospitals NHS Foundation Trust
  • Janice L. Atkins(Author)
    University of Exeter
  • Nuno Mendonça(Author)
    Newcastle University
    Universidade NOVA de Lisboa
  • Katy Horner(Author)
    University College Dublin
  • Esme R. Tuttiett(Author)
    The University of Sheffield
  • Yvie Morgan(Author)
    University of East Anglia
  • Phil Heslop(Author)
    Newcastle University
  • Elizabeth A. Williams(Author)
    The University of Sheffield
  • Claire J. Steves(Author)
    King's College London
    St. Thomas' Hospital, London
  • Carolyn Greig(Author)
    University of Birmingham
    University of Nottingham
    University Hospitals Birmingham NHS Foundation Trust
  • John Draper(Author)
  • Clare A. Corish(Author)
    University College Dublin
  • Ailsa Welch(Author)
    University of East Anglia
  • Miles D. Witham(Author)
    Newcastle University
    Newcastle upon Tyne Hospitals NHS Foundation Trust
  • Avan A. Sayer(Author)
    Newcastle University
    Newcastle upon Tyne Hospitals NHS Foundation Trust
  • Sian Robinson(Author)
    Newcastle University
    Newcastle upon Tyne Hospitals NHS Foundation Trust
Type Article
Original languageEnglish
Article numbere2349
Number of pages20
JournalNutrients
Volume13
Issue number7
DOI
Publication statusPublished - 09 Jul 2021
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Abstract

Frailty is a syndrome of growing importance given the global ageing population. While frailty is a multifactorial process, poor nutritional status is considered a key contributor to its path-ophysiology. As nutrition is a modifiable risk factor for frailty, strategies to prevent and treat frailty should consider dietary change. Observational evidence linking nutrition with frailty appears most robust for dietary quality: for example, dietary patterns such as the Mediterranean diet appear to be protective. In addition, research on specific foods, such as a higher consumption of fruit and vegetables and lower consumption of ultra-processed foods are consistent, with healthier profiles linked to lower frailty risk. Few dietary intervention studies have been conducted to date, although a growing number of trials that combine supplementation with exercise training suggest a multi-domain approach may be more effective. This review is based on an interdisciplinary workshop, held in November 2020, and synthesises current understanding of dietary influences on frailty, focusing on opportunities for prevention and treatment. Longer term prospective studies and well-designed trials are needed to determine the causal effects of nutrition on frailty risk and progression and how dietary change can be used to prevent and/or treat frailty in the future.

Keywords

  • Ageing, Appetite, Frailty, Inflammation, Metabolome, Microbiome

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