Iminosugars from Baphia mitida Lodd

Authors Organisations
  • Atsushi Kato(Author)
    University of Toyama
  • Noriko Kato(Author)
    University of Toyama
  • Saori Miyauchi(Author)
    University of Toyama
  • Yuka Minoshima(Author)
    University of Toyama
  • Isao Adachi(Author)
    University of Toyama
  • Kyoko Ikeda(Author)
    Hokuriku University
  • Naoki Asano(Author)
    Hokuriku University
  • Alison Watson(Author)
    Institute of Grassland and Environmental Research
  • Robert J. Nash(Author)
    Institute of Grassland and Environmental Research
Type Article
Original languageEnglish
Pages (from-to)1261-1265
Number of pages5
Issue number5
Publication statusPublished - Mar 2008
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Chromatographic separation of the 50% aqueous EtOH extract of the leaves of the African medicinal tree Baphia nitida resulted in isolation of 10 iminosugars. The plant contained 2R,5R-dihydroxymethyl-3R,4R-dihydroxypyrrolidine (DMDP) as a major alkaloid. The structure of a new alkaloid was also elucidated by spectroscopic methods as the 1-O-β-d-fructofuranoside of DMDP, and this plant produced 3-O-β-d-glucopyranosyl-DMDP as well. DMDP is a potent inhibitor of β-glucosidase and β-galactosidase, whereas the other two derivatives lowered inhibition toward both of these enzymes and improved inhibitory activities toward rice α-glucosidase and rat intestinal maltase.