Identification of higher brain centres that may encode the cardiorespiratory response to exercise in humans

Authors Organisations
  • Judith Thornton(Author)
    University Laboratory of Physiology
  • Abe Guz(Author)
    University Laboratory of Physiology
  • Kevin Murphy(Author)
    Imperial College London
  • Alison R. Griffith(Author)
    University Laboratory of Physiology
  • David L. Pedersen(Author)
    University Laboratory of Physiology
    University of Oxford
  • Attila Kardos(Author)
    John Radcliffe Hospital (Oxford University Hospital)
  • Alex Leff(Author)
    Hammersmith Hospital
  • Lewis Adams(Author)
    Imperial College London
  • Barbara Casadei(Author)
    John Radcliffe Hospital (Oxford University Hospital)
  • David J. Paterson(Author)
    University Laboratory of Physiology
Type Article
Original languageEnglish
Pages (from-to)823-836
Number of pages14
JournalJournal of Physiology
Issue number3
Publication statusPublished - 15 Jun 2001
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1. Positron emission tomography (PET) was used to identify the neuroanatomical correlates underlying 'central command' during imagination of exercise under hypnosis, in order to uncouple central command from peripheral feedback. 

2. Three cognitive conditions were used: condition I, imagination of freewheeling downhill on a bicycle (no change in heart rate, HR, or ventilation, VI): condition II, imagination of exercise, cycling uphill (increased HR by 12% and VI by 30% of the actual exercise response): condition III, volitionally driven hyperventilation to match that achieved in condition II (no change in HR). 

3. Subtraction methodology created contrast A (II minus I) highlighting cerebral areas involved in the imagination of exercise and contrast B (III minus I) highlighting areas activated in the direct volitional control of breathing (n=4 for both; 8 scans per subject). End-tidal PCO2 (PET,CO2) was held constant throughout PET scanning. 

4. In contrast A, significant activations were seen in the right dorso-lateral prefrontal cortex, supplementary motor areas (SMA), the right premotor area (PMA), superolateral sensorimotor areas, thalamus, and bilaterally in the cerebellum. In contrast B, significant activations were present in the SMA and in lateral sensorimotor cortical areas. The SMA/PMA, dorso-lateral prefrontal cortex and the cerebellum are concerned with volitional/motor control, including that of the respiratory muscles. 

5. The neuroanatomical areas activated suggest that a significant component of the respiratory response to 'exercise', in the absence of both movement feedback and an increase in CO2 production, can be generated by what appears to be a behavioural response.