Harnessing benefits of finger millet in combating micronutrient malnutrition through genetics and genomic approaches

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Harnessing benefits of finger millet in combating micronutrient malnutrition through genetics and genomic approaches. / Puranik, Swati; Godfrey Philliam, Apangu; Ojulong, Henry; Yadav, Rattan.

2016. Poster session presented at CGIAR Research Program on Dryland Cereals Review Meeting, HYDERABAD, India.

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Puranik S, Godfrey Philliam A, Ojulong H, Yadav R. Harnessing benefits of finger millet in combating micronutrient malnutrition through genetics and genomic approaches. 2016. Poster session presented at CGIAR Research Program on Dryland Cereals Review Meeting, HYDERABAD, India.

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Puranik, Swati ; Godfrey Philliam, Apangu ; Ojulong, Henry ; Yadav, Rattan. / Harnessing benefits of finger millet in combating micronutrient malnutrition through genetics and genomic approaches. Poster session presented at CGIAR Research Program on Dryland Cereals Review Meeting, HYDERABAD, India.

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@conference{3938a2b1a5574e858b9255103a9d100d,
title = "Harnessing benefits of finger millet in combating micronutrient malnutrition through genetics and genomic approaches",
abstract = "Micronutrient malnutrition, characterised by vitamins and mineral deficiency, affects almost 2 billion people across all age-groups and genders and is endemic to both developing and developed countries. Besides causing specific deficiencies, it also aggravates other infectious and chronic diseases, resulting in almost 80% deaths in developing regions. Identifying health benefitting characteristics and micronutritional richness in traditional crops, and breeding them into staple crops consumed on daily basis, offers a low cost sustainable food-based solution to the problem. A traditional crop grown in most marginal areas of Africa and Asia, finger millet, is a rich source of health benefitting micronutrients, phytochemicals, vitamins and several essential amino acids. To better understand genetic control of these health benefitting traits and to breed them effectively into other staple crops, we are making use of genetics and genomics approaches. We have assembled a set of 190 genotypes incorporating a minicore collection of finger millet together with a number of elite breeding lines to capture and characterise entire genetic variation associated with such traits in finger millet gene bank. These genotypes have been extensively characterised for micronutrients (such as iron, zinc, calcium, magnesium, sodium, and potassium), protein and anti-nutrients (phytate and oxalate). Further, large-scale genotype-by-sequencing performed on these genotypes has generated 156,157 SNPs across these germplasms and breeding lines. Genome-wide association analysis of these data has identified a number of genomic regions associated with both the health benefitting traits as well as with other factors that affect their bioavailability. These findings are also paving ways of assessing how such genetic variations are distributed in other staple crops. Progress made in the project so far and of our future directions will be discussed.",
keywords = "Finger millet, Micronutrients, Minerals, Genotyping-by sequencing, Genome-wide association analysis, Health benefitting traits",
author = "Swati Puranik and {Godfrey Philliam}, Apangu and Henry Ojulong and Rattan Yadav",
year = "2016",
month = sep,
day = "21",
language = "English",
note = "CGIAR Research Program on Dryland Cereals Review Meeting, CRP DC ; Conference date: 03-10-2016 Through 05-10-2016",

}

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TY - CONF

T1 - Harnessing benefits of finger millet in combating micronutrient malnutrition through genetics and genomic approaches

AU - Puranik, Swati

AU - Godfrey Philliam, Apangu

AU - Ojulong, Henry

AU - Yadav, Rattan

PY - 2016/9/21

Y1 - 2016/9/21

N2 - Micronutrient malnutrition, characterised by vitamins and mineral deficiency, affects almost 2 billion people across all age-groups and genders and is endemic to both developing and developed countries. Besides causing specific deficiencies, it also aggravates other infectious and chronic diseases, resulting in almost 80% deaths in developing regions. Identifying health benefitting characteristics and micronutritional richness in traditional crops, and breeding them into staple crops consumed on daily basis, offers a low cost sustainable food-based solution to the problem. A traditional crop grown in most marginal areas of Africa and Asia, finger millet, is a rich source of health benefitting micronutrients, phytochemicals, vitamins and several essential amino acids. To better understand genetic control of these health benefitting traits and to breed them effectively into other staple crops, we are making use of genetics and genomics approaches. We have assembled a set of 190 genotypes incorporating a minicore collection of finger millet together with a number of elite breeding lines to capture and characterise entire genetic variation associated with such traits in finger millet gene bank. These genotypes have been extensively characterised for micronutrients (such as iron, zinc, calcium, magnesium, sodium, and potassium), protein and anti-nutrients (phytate and oxalate). Further, large-scale genotype-by-sequencing performed on these genotypes has generated 156,157 SNPs across these germplasms and breeding lines. Genome-wide association analysis of these data has identified a number of genomic regions associated with both the health benefitting traits as well as with other factors that affect their bioavailability. These findings are also paving ways of assessing how such genetic variations are distributed in other staple crops. Progress made in the project so far and of our future directions will be discussed.

AB - Micronutrient malnutrition, characterised by vitamins and mineral deficiency, affects almost 2 billion people across all age-groups and genders and is endemic to both developing and developed countries. Besides causing specific deficiencies, it also aggravates other infectious and chronic diseases, resulting in almost 80% deaths in developing regions. Identifying health benefitting characteristics and micronutritional richness in traditional crops, and breeding them into staple crops consumed on daily basis, offers a low cost sustainable food-based solution to the problem. A traditional crop grown in most marginal areas of Africa and Asia, finger millet, is a rich source of health benefitting micronutrients, phytochemicals, vitamins and several essential amino acids. To better understand genetic control of these health benefitting traits and to breed them effectively into other staple crops, we are making use of genetics and genomics approaches. We have assembled a set of 190 genotypes incorporating a minicore collection of finger millet together with a number of elite breeding lines to capture and characterise entire genetic variation associated with such traits in finger millet gene bank. These genotypes have been extensively characterised for micronutrients (such as iron, zinc, calcium, magnesium, sodium, and potassium), protein and anti-nutrients (phytate and oxalate). Further, large-scale genotype-by-sequencing performed on these genotypes has generated 156,157 SNPs across these germplasms and breeding lines. Genome-wide association analysis of these data has identified a number of genomic regions associated with both the health benefitting traits as well as with other factors that affect their bioavailability. These findings are also paving ways of assessing how such genetic variations are distributed in other staple crops. Progress made in the project so far and of our future directions will be discussed.

KW - Finger millet

KW - Micronutrients

KW - Minerals

KW - Genotyping-by sequencing, Genome-wide association analysis

KW - Health benefitting traits

UR - http://hdl.handle.net/2160/43785

M3 - Poster

T2 - CGIAR Research Program on Dryland Cereals Review Meeting

Y2 - 3 October 2016 through 5 October 2016

ER -

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