Experimental infection models of tuberculosis in domestic livestock

Authors Organisations
  • Bryce M. Buddle(Author)
    Massey University Manawatu
  • H. Martin Vordermeier(Author)
    Animal and Plant Health Agency
  • Glyn Hewinson(Author)
    Animal and Plant Health Agency
Type Article
Original languageEnglish
Article numberTBTB2-0017-2016
Number of pages15
JournalMicrobiology Spectrum
Volume4
Issue number4
DOI
Publication statusPublished - 26 Aug 2016
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Abstract

In this article we present experimental Mycobacterium bovis infection models in domestic livestock species and how these models were applied to vaccine development, biomarker discovery, and the definition of specific antigens for the differential diagnosis of infected and vaccinated animals. In particular, we highlight synergies between human and bovine tuberculosis (TB) research approaches and data and propose that the application of bovine TB models could make a valuable contribution to human TB vaccine research and that close alignment of both research programs in a one health philosophy will lead to mutual and substantial benefits.