(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

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(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach. / Cosseau, Celine; Wolkenhauer, Olaf; Padalino, Gilda; Geyer, Kathrin; Hoffmann, Karl; Grunau, Christoph.

In: Trends in Parasitology, Vol. 33, No. 4, 01.04.2017, p. 285-294.

Research output: Contribution to journalArticle

Harvard

Cosseau, C, Wolkenhauer, O, Padalino, G, Geyer, K, Hoffmann, K & Grunau, C 2017, '(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach' Trends in Parasitology, vol. 33, no. 4, pp. 285-294. https://doi.org/10.1016/j.pt.2016.12.002

APA

Cosseau, C., Wolkenhauer, O., Padalino, G., Geyer, K., Hoffmann, K., & Grunau, C. (2017). (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach. Trends in Parasitology, 33(4), 285-294. https://doi.org/10.1016/j.pt.2016.12.002

Vancouver

Cosseau C, Wolkenhauer O, Padalino G, Geyer K, Hoffmann K, Grunau C. (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach. Trends in Parasitology. 2017 Apr 1;33(4):285-294. https://doi.org/10.1016/j.pt.2016.12.002

Author

Cosseau, Celine ; Wolkenhauer, Olaf ; Padalino, Gilda ; Geyer, Kathrin ; Hoffmann, Karl ; Grunau, Christoph. / (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach. In: Trends in Parasitology. 2017 ; Vol. 33, No. 4. pp. 285-294.

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@article{b1f64e30693048c98e44a57321ee5de9,
title = "(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach",
abstract = "The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.",
author = "Celine Cosseau and Olaf Wolkenhauer and Gilda Padalino and Kathrin Geyer and Karl Hoffmann and Christoph Grunau",
year = "2017",
month = "4",
day = "1",
doi = "10.1016/j.pt.2016.12.002",
language = "English",
volume = "33",
pages = "285--294",
journal = "Trends in Parasitology",
issn = "1471-4922",
publisher = "Elsevier",
number = "4",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

AU - Cosseau, Celine

AU - Wolkenhauer, Olaf

AU - Padalino, Gilda

AU - Geyer, Kathrin

AU - Hoffmann, Karl

AU - Grunau, Christoph

PY - 2017/4/1

Y1 - 2017/4/1

N2 - The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.

AB - The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.

UR - http://hdl.handle.net/2160/44418

U2 - 10.1016/j.pt.2016.12.002

DO - 10.1016/j.pt.2016.12.002

M3 - Article

VL - 33

SP - 285

EP - 294

JO - Trends in Parasitology

JF - Trends in Parasitology

SN - 1471-4922

IS - 4

ER -

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