Enhanced resting-state functional connectivity between core memory-task activation peaks is associated with memory impairment in MCI

Authors Organisations
  • Yifei Zhang(Author)
    Ludwig Maximilian University of Munich
    Shanghai University
  • Lee Simon-Vermot(Author)
    Ludwig Maximilian University of Munich
  • Miguel Á. Araque Caballero(Author)
    Ludwig Maximilian University of Munich
  • Benno Gesierich(Author)
    Ludwig Maximilian University of Munich
  • Alexander Taylor(Author)
    Ludwig Maximilian University of Munich
  • Marco Duering(Author)
    Ludwig Maximilian University of Munich
  • Martin Dichgans(Author)
    Munich Cluster for Systems Neurology (SyNergy)
    Ludwig Maximilian University of Munich
  • Michael Ewers(Author)
    Ludwig Maximilian University of Munich
Type Article
Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalNeurobiology of Aging
Early online date03 May 2016
Publication statusPublished - 30 Sept 2016
Externally publishedYes
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Resting-state functional connectivity (FC) is altered in Alzheimer's disease (AD) but its predictive value for episodic memory impairment is debated. Here, we aimed to assess whether resting-state FC in core brain regions activated during memory-task functional magnetic resonance imaging is altered and predictive of memory performance in AD and amnestic mild cognitive impairment (aMCI). Twenty-three elderly cognitively healthy controls (HC), 76 aMCI subjects, and 19 AD dementia patients were included. We computed resting-state FC between 18 meta-analytically determined peak coordinates of brain activation during successful memory retrieval. Higher FC between the parahippocampus, parietal cortex, and the middle frontal gyrus was observed in both AD and mild cognitive impairment compared to HC (false-discovery rate—corrected p < 0.05). The increase in FC between the parahippocampus and middle frontal gyrus was associated with reduced episodic memory in aMCI, independent of amyloid-beta positron emission tomography binding and apolipoprotein E ε4-carrier status. In conclusion, increased parahippocampal-prefrontal FC is predictive of impaired episodic memory in aMCI and may reflect a dysfunctional change within the episodic memory–related neural network.


  • Alzheimer's disease, Functional connectivity, Episodic memory, mild cognitive impairment, Resting-state functional MRI, Compensation, Network