Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs

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Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs. / Allison, G. G.; Rees Stevens, P.; Heasman, L.; Davies, A.; Jackman, R.; Moorby, J. M.

In: Veterinary Research Communications, Vol. 32, No. 8, 01.12.2008, p. 591-597.

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Allison, G. G. ; Rees Stevens, P. ; Heasman, L. ; Davies, A. ; Jackman, R. ; Moorby, J. M. / Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs. In: Veterinary Research Communications. 2008 ; Vol. 32, No. 8. pp. 591-597.

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@article{7bcf1ed572b74495a72c4c89a50ea6d7,
title = "Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs",
abstract = "Three groups of two weeks old growing lambs differing in PrP genotype were orally inoculated with scrapie and maintained under defined conditions until disease endpoint. Plasma concentrations of free alanine and serine, but not L-lactate increased during the final 6 months of the disease. At the same time, plasma concentrations of several essential and non-essential free amino acids decreased linearly, indicating reduced feed intake and are consistent with, but occurring before establishment, of cachexia. These observations are consistent with those reported previously from studies on cattle infected with BSE and with the hypothesis that scrapie may effect peripheral tissue metabolism.",
keywords = "scrapie, lambs, plasma, amino acid, L-lactate, metabolism",
author = "Allison, {G. G.} and {Rees Stevens}, P. and L. Heasman and A. Davies and R. Jackman and Moorby, {J. M.}",
note = "IMPF: 00.63 RONO: 1930 4055 ",
year = "2008",
month = dec,
day = "1",
doi = "10.1007/s11259-008-9067-5",
language = "English",
volume = "32",
pages = "591--597",
journal = "Veterinary Research Communications",
issn = "0165-7380",
publisher = "Springer Nature",
number = "8",

}

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TY - JOUR

T1 - Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs

AU - Allison, G. G.

AU - Rees Stevens, P.

AU - Heasman, L.

AU - Davies, A.

AU - Jackman, R.

AU - Moorby, J. M.

N1 - IMPF: 00.63 RONO: 1930 4055

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Three groups of two weeks old growing lambs differing in PrP genotype were orally inoculated with scrapie and maintained under defined conditions until disease endpoint. Plasma concentrations of free alanine and serine, but not L-lactate increased during the final 6 months of the disease. At the same time, plasma concentrations of several essential and non-essential free amino acids decreased linearly, indicating reduced feed intake and are consistent with, but occurring before establishment, of cachexia. These observations are consistent with those reported previously from studies on cattle infected with BSE and with the hypothesis that scrapie may effect peripheral tissue metabolism.

AB - Three groups of two weeks old growing lambs differing in PrP genotype were orally inoculated with scrapie and maintained under defined conditions until disease endpoint. Plasma concentrations of free alanine and serine, but not L-lactate increased during the final 6 months of the disease. At the same time, plasma concentrations of several essential and non-essential free amino acids decreased linearly, indicating reduced feed intake and are consistent with, but occurring before establishment, of cachexia. These observations are consistent with those reported previously from studies on cattle infected with BSE and with the hypothesis that scrapie may effect peripheral tissue metabolism.

KW - scrapie

KW - lambs

KW - plasma

KW - amino acid

KW - L-lactate

KW - metabolism

UR - http://hdl.handle.net/2160/7973

U2 - 10.1007/s11259-008-9067-5

DO - 10.1007/s11259-008-9067-5

M3 - Article

C2 - 18548327

VL - 32

SP - 591

EP - 597

JO - Veterinary Research Communications

JF - Veterinary Research Communications

SN - 0165-7380

IS - 8

ER -

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