Effect of scrapie incubation on the concentrations of plasma amino acids and L-lactate in infected lambs

Type Article
Original languageEnglish
Pages (from-to)591-597
Number of pages7
JournalVeterinary Research Communications
Volume32
Issue number8
Early online date12 Jun 2008
DOI
Publication statusPublished - 01 Dec 2008
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Abstract

Three groups of two weeks old growing lambs differing in PrP genotype were orally inoculated with scrapie and maintained under defined conditions until disease endpoint. Plasma concentrations of free alanine and serine, but not L-lactate increased during the final 6 months of the disease. At the same time, plasma concentrations of several essential and non-essential free amino acids decreased linearly, indicating reduced feed intake and are consistent with, but occurring before establishment, of cachexia. These observations are consistent with those reported previously from studies on cattle infected with BSE and with the hypothesis that scrapie may effect peripheral tissue metabolism.

Keywords

  • scrapie, lambs, plasma, amino acid, L-lactate, metabolism