Anthelmintic metabolism in parasitic helminths: proteomic insights

P. M. Brophy; N. Mackintosh; R. M. Morphew

doi:10.1017/S003118201200087X

Anthelmintic metabolism in parasitic helminths: proteomic insights

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Anthelmintic metabolism in parasitic helminths: proteomic insights. / Brophy, P. M.; Mackintosh, N.; Morphew, R. M.

In: Parasitology, Vol. 139, No. 9, 08.2012, p. 1205-1217.

Research output: Contribution to journal › Article › peer-review

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@article{b39b887fb54b4f7bb1a3687596b3bad5,

title = "Anthelmintic metabolism in parasitic helminths: proteomic insights",

abstract = "SUMMARY Anthelmintics are the cornerstone of parasitic helminth control. Surprisingly, understanding of the biochemical pathways used by parasitic helminths to detoxify anthelmintics is fragmented, despite the increasing global threat of anthelmintic resistance within the ruminant and equine industries. Reductionist biochemistry has likely over-estimated the enzymatic role of glutathione transferases in anthelmintic metabolism and neglected the potential role of the cytochrome P-450 superfamily (CYPs). Proteomic technologies offers the opportunity to support genomics, reverse genetics and pharmacokinetics, and provide an integrated insight into both the cellular mechanisms underpinning response to anthelmintics and also the identification of biomarker panels for monitoring the development of anthelmintic resistance. To date, there have been limited attempts to include proteomics in anthelmintic metabolism studies. Optimisations of membrane, post-translational modification and interaction proteomic technologies in helminths are needed to especially study Phase I CYPs and Phase III ABC transporter pumps for anthelmintics and their metabolites.",

author = "Brophy, {P. M.} and N. Mackintosh and Morphew, {R. M.}",

note = "Brophy, P. M., Mackintosh, N., Morphew, R. M. (2012). Anthelmintic metabolism in parasitic helminths: proteomic insights. Parasitology, 139 (9), 1205-1217.",

year = "2012",

month = aug,

doi = "10.1017/S003118201200087X",

language = "English",

volume = "139",

pages = "1205--1217",

journal = "Parasitology",

issn = "0031-1820",

publisher = "Cambridge University Press",

number = "9",

}

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TY - JOUR

T1 - Anthelmintic metabolism in parasitic helminths: proteomic insights

AU - Brophy, P. M.

AU - Mackintosh, N.

AU - Morphew, R. M.

N1 - Brophy, P. M., Mackintosh, N., Morphew, R. M. (2012). Anthelmintic metabolism in parasitic helminths: proteomic insights. Parasitology, 139 (9), 1205-1217.

PY - 2012/8

Y1 - 2012/8

N2 - SUMMARY Anthelmintics are the cornerstone of parasitic helminth control. Surprisingly, understanding of the biochemical pathways used by parasitic helminths to detoxify anthelmintics is fragmented, despite the increasing global threat of anthelmintic resistance within the ruminant and equine industries. Reductionist biochemistry has likely over-estimated the enzymatic role of glutathione transferases in anthelmintic metabolism and neglected the potential role of the cytochrome P-450 superfamily (CYPs). Proteomic technologies offers the opportunity to support genomics, reverse genetics and pharmacokinetics, and provide an integrated insight into both the cellular mechanisms underpinning response to anthelmintics and also the identification of biomarker panels for monitoring the development of anthelmintic resistance. To date, there have been limited attempts to include proteomics in anthelmintic metabolism studies. Optimisations of membrane, post-translational modification and interaction proteomic technologies in helminths are needed to especially study Phase I CYPs and Phase III ABC transporter pumps for anthelmintics and their metabolites.

AB - SUMMARY Anthelmintics are the cornerstone of parasitic helminth control. Surprisingly, understanding of the biochemical pathways used by parasitic helminths to detoxify anthelmintics is fragmented, despite the increasing global threat of anthelmintic resistance within the ruminant and equine industries. Reductionist biochemistry has likely over-estimated the enzymatic role of glutathione transferases in anthelmintic metabolism and neglected the potential role of the cytochrome P-450 superfamily (CYPs). Proteomic technologies offers the opportunity to support genomics, reverse genetics and pharmacokinetics, and provide an integrated insight into both the cellular mechanisms underpinning response to anthelmintics and also the identification of biomarker panels for monitoring the development of anthelmintic resistance. To date, there have been limited attempts to include proteomics in anthelmintic metabolism studies. Optimisations of membrane, post-translational modification and interaction proteomic technologies in helminths are needed to especially study Phase I CYPs and Phase III ABC transporter pumps for anthelmintics and their metabolites.

UR - http://hdl.handle.net/2160/8092

U2 - 10.1017/S003118201200087X

DO - 10.1017/S003118201200087X

M3 - Article

C2 - 22776506

VL - 139

SP - 1205

EP - 1217

JO - Parasitology

JF - Parasitology

SN - 0031-1820

IS - 9