An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake

Isabel Garcia-Perez; Joram M Posma; Edward S. Chambers; Jeremy K. Nicholson; John C. Mathers; Manfred Beckmann; John Draper; Elaine Holmes; Gary Frost

doi:10.1021/acs.jafc.5b05878

An Analytical Pipeline for Quantitative Characterization of Dietary IntakeApplication To Assess Grape Intake

Standard

An Analytical Pipeline for Quantitative Characterization of Dietary Intake : Application To Assess Grape Intake. / Garcia-Perez, Isabel; Posma, Joram M; Chambers, Edward S.; Nicholson, Jeremy K.; Mathers, John C.; Beckmann, Manfred ; Draper, John; Holmes, Elaine; Frost, Gary.

In: Journal of Agricultural and Food Chemistry, Vol. 64, No. 11, 23.03.2016, p. 2423-2431.

Research output: Contribution to journal › Article › peer-review

Harvard

Garcia-Perez, I, Posma, JM, Chambers, ES, Nicholson, JK, Mathers, JC, Beckmann, M , Draper, J, Holmes, E & Frost, G 2016, 'An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake', Journal of Agricultural and Food Chemistry, vol. 64, no. 11, pp. 2423-2431. https://doi.org/10.1021/acs.jafc.5b05878

APA

Garcia-Perez, I., Posma, J. M., Chambers, E. S., Nicholson, J. K., Mathers, J. C., Beckmann, M., Draper, J., Holmes, E., & Frost, G. (2016). An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake. Journal of Agricultural and Food Chemistry, 64(11), 2423-2431. https://doi.org/10.1021/acs.jafc.5b05878

Vancouver

Garcia-Perez I, Posma JM, Chambers ES, Nicholson JK, Mathers JC, Beckmann M et al. An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake. Journal of Agricultural and Food Chemistry. 2016 Mar 23;64(11):2423-2431. https://doi.org/10.1021/acs.jafc.5b05878

Author

Garcia-Perez, Isabel ; Posma, Joram M ; Chambers, Edward S. ; Nicholson, Jeremy K. ; Mathers, John C. ; Beckmann, Manfred ; Draper, John ; Holmes, Elaine ; Frost, Gary. / An Analytical Pipeline for Quantitative Characterization of Dietary Intake : Application To Assess Grape Intake. In: Journal of Agricultural and Food Chemistry. 2016 ; Vol. 64, No. 11. pp. 2423-2431.

Bibtex - Download

@article{836b8f2802f7495294ea2c69ff211975,

title = "An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application To Assess Grape Intake",

abstract = "Lack of accurate dietary assessment in free-living populations requires discovery of new biomarkers reflecting food intake qualitatively and quantitatively to objectively evaluate effects of diet on health. We provide a proof-of-principle for an analytical pipeline to identify quantitative dietary biomarkers. Tartaric acid was identified by nuclear magnetic resonance spectroscopy as a dose-responsive urinary biomarker of grape intake and subsequently quantified in volunteers following a series of 4-day dietary interventions incorporating 0 g/day, 50 g/day, 100 g/day, and 150 g/day of grapes in standardized diets from a randomized controlled clinical trial. Most accurate quantitative predictions of grape intake were obtained in 24 h urine samples which have the strongest linear relationship between grape intake and tartaric acid excretion (r(2) = 0.90). This new methodological pipeline for estimating nutritional intake based on coupling dietary intake information and quantified nutritional biomarkers was developed and validated in a controlled dietary intervention study, showing that this approach can improve the accuracy of estimating nutritional intakes.",

keywords = "accurate dietary assessment, metabolic profiling, nutritional intake, quantified dietary biomarkers, tartaric acid",

author = "Isabel Garcia-Perez and Posma, {Joram M} and Chambers, {Edward S.} and Nicholson, {Jeremy K.} and Mathers, {John C.} and Manfred Beckmann and John Draper and Elaine Holmes and Gary Frost",

year = "2016",

month = mar,

day = "23",

doi = "10.1021/acs.jafc.5b05878",

language = "English",

volume = "64",

pages = "2423--2431",

journal = "Journal of Agricultural and Food Chemistry",

issn = "0021-8561",

publisher = "American Chemical Society",

number = "11",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - An Analytical Pipeline for Quantitative Characterization of Dietary Intake

T2 - Application To Assess Grape Intake

AU - Garcia-Perez, Isabel

AU - Posma, Joram M

AU - Chambers, Edward S.

AU - Nicholson, Jeremy K.

AU - Mathers, John C.

AU - Beckmann, Manfred

AU - Draper, John

AU - Holmes, Elaine

AU - Frost, Gary

PY - 2016/3/23

Y1 - 2016/3/23

N2 - Lack of accurate dietary assessment in free-living populations requires discovery of new biomarkers reflecting food intake qualitatively and quantitatively to objectively evaluate effects of diet on health. We provide a proof-of-principle for an analytical pipeline to identify quantitative dietary biomarkers. Tartaric acid was identified by nuclear magnetic resonance spectroscopy as a dose-responsive urinary biomarker of grape intake and subsequently quantified in volunteers following a series of 4-day dietary interventions incorporating 0 g/day, 50 g/day, 100 g/day, and 150 g/day of grapes in standardized diets from a randomized controlled clinical trial. Most accurate quantitative predictions of grape intake were obtained in 24 h urine samples which have the strongest linear relationship between grape intake and tartaric acid excretion (r(2) = 0.90). This new methodological pipeline for estimating nutritional intake based on coupling dietary intake information and quantified nutritional biomarkers was developed and validated in a controlled dietary intervention study, showing that this approach can improve the accuracy of estimating nutritional intakes.

AB - Lack of accurate dietary assessment in free-living populations requires discovery of new biomarkers reflecting food intake qualitatively and quantitatively to objectively evaluate effects of diet on health. We provide a proof-of-principle for an analytical pipeline to identify quantitative dietary biomarkers. Tartaric acid was identified by nuclear magnetic resonance spectroscopy as a dose-responsive urinary biomarker of grape intake and subsequently quantified in volunteers following a series of 4-day dietary interventions incorporating 0 g/day, 50 g/day, 100 g/day, and 150 g/day of grapes in standardized diets from a randomized controlled clinical trial. Most accurate quantitative predictions of grape intake were obtained in 24 h urine samples which have the strongest linear relationship between grape intake and tartaric acid excretion (r(2) = 0.90). This new methodological pipeline for estimating nutritional intake based on coupling dietary intake information and quantified nutritional biomarkers was developed and validated in a controlled dietary intervention study, showing that this approach can improve the accuracy of estimating nutritional intakes.

KW - accurate dietary assessment

KW - metabolic profiling

KW - nutritional intake

KW - quantified dietary biomarkers

KW - tartaric acid

UR - http://hdl.handle.net/2160/42655

U2 - 10.1021/acs.jafc.5b05878

DO - 10.1021/acs.jafc.5b05878

M3 - Article

C2 - 26909845

VL - 64

SP - 2423