An Analytical Pipeline for Quantitative Characterization of Dietary IntakeApplication To Assess Grape Intake
Type | Article |
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Original language | English |
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Pages (from-to) | 2423-2431 |
Number of pages | 9 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 64 |
Issue number | 11 |
Early online date | 24 Feb 2016 |
DOI | |
Publication status | Published - 23 Mar 2016 |
Links |
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Permanent link | Permanent link |
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Abstract
Lack of accurate dietary assessment in free-living populations requires discovery of new biomarkers reflecting food intake qualitatively and quantitatively to objectively evaluate effects of diet on health. We provide a proof-of-principle for an analytical pipeline to identify quantitative dietary biomarkers. Tartaric acid was identified by nuclear magnetic resonance spectroscopy as a dose-responsive urinary biomarker of grape intake and subsequently quantified in volunteers following a series of 4-day dietary interventions incorporating 0 g/day, 50 g/day, 100 g/day, and 150 g/day of grapes in standardized diets from a randomized controlled clinical trial. Most accurate quantitative predictions of grape intake were obtained in 24 h urine samples which have the strongest linear relationship between grape intake and tartaric acid excretion (r(2) = 0.90). This new methodological pipeline for estimating nutritional intake based on coupling dietary intake information and quantified nutritional biomarkers was developed and validated in a controlled dietary intervention study, showing that this approach can improve the accuracy of estimating nutritional intakes.
Keywords
- accurate dietary assessment, metabolic profiling, nutritional intake, quantified dietary biomarkers, tartaric acid
Documents
- An Analytical Pipeline for Quantitative Characterization of Dietary Intake: Application to Assess Grape Intake
Accepted author manuscript, 1.75 MB, PDF
Licence: CC BY-NC Show licence
- Supporting Information
Data, 389 KB, PDF