Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders

Authors Organisations
  • Konstantin N. Zabegalov(Author)
    Southwest University for Nationalities
    Ural Federal University
  • Sergey L. Khatsko(Author)
    Ural Federal University
  • Anton M. Lakstygal(Author)
    Saint Petersburg State University
    Granov Russian Scientific Center of Radiology and Surgical Technologies
  • Konstantin A. Demin(Author)
    Almazov National Medical Research Centre
    Saint Petersburg State University
  • Madeleine Cleal(Author)
    University of Portsmouth
  • Barbara D. Fontana(Author)
    University of Portsmouth
  • Sebastian McBride(Author)
  • Brian Harvey(Author)
    North-West University (NWU)
    South African Medical Research Council Unit on Risk and Resilience in Mental Disorders
  • Murilo S. de Abreu(Author)
    The International Zebrafish Neuroscience Research Consortium (ZNRC)
    University of Passo Fundo
  • Matthew O. Parker(Author)
    University of Portsmouth
  • Allan V. Kalueff(Author)
Type Article
Original languageEnglish
Pages (from-to)101-110
Number of pages10
JournalBehavioural Brain Research
Volume367
Early online date27 Mar 2019
DOI
Publication statusPublished - 23 Jul 2019
View graph of relations
Citation formats

Abstract

Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to clear practical research advantages as a model species, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and robust behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive behaviors in zebrafish, data on their genetic and pharmacological modulation, and the overall translational relevance of fish ARBs to modeling human brain disorders. Overall, the zebrafish is rapidly emerging as a new promising model to study ARBs and their underlying mechanisms.

Keywords

  • zebrafish, abnormal repetitive behavior, stereotypy, animal models, human brain disorders

Documents

  • Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders

    Accepted author manuscript, 429 KB, PDF

    Embargo ends: 27 Mar 2020

    Request copy

    Licence: CC BY-NC-ND Show licence