Developing a 'Validation Portfolio' to Exploit Key Virulence Proteins in Fasciola Species for Parasite Control

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  1. 2022
  2. Published

    In silico characterisation of the complete Ly6 protein family in Fasciola gigantica supported through transcriptomics of the newly-excysted juveniles

    Davey, S., Chalmers, I., Fernandez Fuentes, N., Swain, M., Smith, D., Abbas Abidi, S. M., Saifullah, M. K., Raman, M., Ravikumar, G., McVeigh, P., Maule, A. G., Brophy, P. & Morphew, R., 17 Jan 2022, In: Molecular Omics. 18, 1, p. 45-56 12 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1039/D1MO00254F
  3. 2019
  4. Published

    X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment

    Line, K., Isupov, M. N., LaCourse, E. J., Cutress, D., Morphew, R., Brophy, P. & Littlechild, J. A., 29 Jan 2019, In: Scientific Reports. 9, 902.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1038/s41598-018-37531-5
  5. 2016
  6. Published

    Exploring and Expanding the Fatty-Acid-Binding Protein Superfamily in Fasciola Species

    Morphew, R., Wilkinson, T., MacKintosh, N., Jahndel, V., Paterson, S., McVeigh, P., Abbas Abidi, S. M., Saifullah, K., Raman, M., Ravikumar , G., LaCourse, E. J., Maule, A. G. & Brophy, P., 06 Aug 2016, In: Journal of Proteome Research. 15, 9, p. 3308-3321 14 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1021/acs.jproteome.6b00331
  7. Published

    Calmodulin disruption impacts growth and motility in juvenile liver fluke

    McCammick, E., McVeigh, P., McCusker, P., Timson, D., Morphew, R., Brophy, P., Marks, N., Mousley, A. & Maule, A., 27 Jan 2016, In: Parasites & Vectors. 9, N/A, 13 p., 46.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1186/s13071-016-1324-9
  8. 2014
  9. Published

    RNAi dynamics in juvenile Fasciola spp. liver flukes reveals the persistence of gene silencing in vitro

    McVeigh, P., McCammick, E., McCusker, P., Morphew, R., Mousley, A., Abidi, A., Saifullah, K. M., Muthusamy, R., Gopalakrishnan, R., Spithill, T. W., Dalton, J. P., Brophy, P., Marks, N. J. & Maule, A. G., 25 Sep 2014, In: PLoS Neglected Tropical Diseases. 8, 9, 13 p., e3185.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1371/journal.pntd.0003185
  10. Published

    Time-dependent tegumental surface changes in juvenile Fasciola gigantica in response to triclabendazole treatment in goat

    Ahammed Shareef, P. A., Brennan, G. P., McVeigh, P., Hannan Khan, M. A., Morphew, R., Mousley, A., Marks, N. J., Khalid Saifullah, M. K., Brophy, P., Maule, A. G. & Abidi, S. M. A., Aug 2014, In: Acta Tropica. 136, p. 108-117 10 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.actatropica.2014.04.011
  11. 2013
  12. Published

    Early hepatic and peritoneal changes and immune response in goats vaccinated with a recombinant glutathione transferase sigma class and challenged with Fasciola hepatica.

    Zafra, R., Pérez-Écija, R. A., Buffoni, L., Pacheco, I. L., Martínez-Moreno, A., Lacourse , E. J., Perally, S., Brophy, P. & Pérez, J., 01 Jun 2013, In: Research in Veterinary Science. 94, 3, p. 602-609 8 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.rvsc.2012.10.026
  13. Published

    Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica resleased by Nonident P40

    Morphew, R., Hamilton, C. M., Wright, H. A., Dowling, D. J., O'Neill, S. M. & Brophy, P., 31 Jan 2013, In: Veterinary Parasitology. 191, 3-4, p. 379–385

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1016/j.vetpar.2012.08.029
  14. 2012
  15. Published

    Anthelmintic metabolism in parasitic helminths: proteomic insights

    Brophy, P., MacKintosh, N. & Morphew, R., Aug 2012, In: Parasitology. 139, 9, p. 1205-1217 13 p.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1017/S003118201200087X
  16. Published

    The Sigma Class glutathione transferase from the liver fluke Fasciola hepatica

    LaCourse, E. J., Perally, S., Morphew, R., Moxon, J. V., Prescott, M. C., Dowling, D. J., O'Neill, S. M., Kipar, A., Hetzel, U., Hoey, E., Zafra, R., Buffoni, L., Arévalo, J. P. & Brophy, P., 01 May 2012, In: PLoS Neglected Tropical Diseases. 6, 5, p. n/a e1666.

    Research output: Contribution to journal › Article › peer-review

    DOI: 10.1371/journal.pntd.0001666
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