Prof Karl Hoffmann PhD
Professor
- ProfessorDepartment of Biological, Environmental and Rural Sciences - Teaching And Research
Department of Biological, Environmental and Rural Sciences
Postal address
Aberystwyth University
Edward Llwyd Building
Penglais
Aberystwyth
Edward Llwyd Building
Penglais
Aberystwyth
United Kingdom of Great Britain and Northern Ireland
Link(s)
ORCID: 0000-0002-3932-5502
- 2021
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation
Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D. S. G., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A. & Hoffmann, K., 15 Dec 2021, In: European Journal of Medicinal Chemistry. 226, 19 p., 113823.Research output: Contribution to journal › Article › peer-review
Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni
Partridge, F. A., Bataille, C. J. R., Forman, R., Marriott, A. E., Forde-Thomas, J., Häberli, C., Dinsdale, R. L., O'Sullivan, J. D. B., Willis, N. J., Wynne, G. M., Whiteland, H., Archer, J., Steven, A., Keiser, J., Turner, J. D., Hoffmann, K., Taylor, M. J., Else, K. J., Russell, A. J. & Sattelle, D. B., 14 May 2021, In: ACS Infectious Diseases. 7, 5, p. 1260-1274 15 p.Research output: Contribution to journal › Article › peer-review
Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function
Perally, S., Geyer, K. K., Farani, P. S. G., Chalmers, I., Fernandez Fuentes, N., Maskell, D. R., Hulme, B. J., Forde-Thomas, J., Phillips, D., Farias, L. P., Collins, J. J. & Hoffmann, K., 01 Mar 2021, In: International Journal for Parasitology. 51, 4, p. 251-261 11 p.Research output: Contribution to journal › Article › peer-review
Identifying and validating the presence of Guanine-Quadruplexes (G4) within the blood fluke parasite Schistosoma mansoni
Craven, H., Bonsignore, R., Lenis, V., Santi, N., Berrar, D., Swain, M., Whiteland, H., Casini, A. & Hoffmann, K., 18 Feb 2021, In: PLoS Neglected Tropical Diseases. 15, 2, 24 p., e0008770.Research output: Contribution to journal › Article › peer-review
- 2020
Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal
Whiteland, H., Crusco, A., Bloemberg, L. W., Tibble-Howlings, J., Forde-Thomas, J., Coghlan, A., Murphy, P. J. & Hoffmann, K., 19 Oct 2020, In: PLoS Neglected Tropical Diseases. 14, 10, 22 p., e0008630.Research output: Contribution to journal › Article › peer-review
Large-scale RNAi screening uncovers therapeutic targets in the parasite Schistosoma mansoni
Wang, J., Paz, C., Padalino, G., Coghlan, A., Lu, Z., Gradinaru, I., Collins, J. N. R., Berriman, M., Hoffmann, K. & Collins, J. J., 25 Sep 2020, In: Science (New York, N.Y.). 369, 6511, p. 1649-1653 5 p.Research output: Contribution to journal › Article › peer-review
DC‐SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte‐derived dendritic cells
Kuipers, M. E., Nolte-‘t Hoen, E. N. M., van der Ham, A. J., Ozir-Fazalalikhan, A., Nguyen, D. L., de Korne, C. M., Koning, R. I., Tomes, J., Hoffmann, K., Smits, H. H. & Hokke, C. H., 01 Sep 2020, In: Journal of Extracellular Vesicles. 9, 1, 19 p., 1753420.Research output: Contribution to journal › Article › peer-review
- Published
Helminth extracellular vesicles: Great balls of wonder
Hoffmann, K., Hokke, C. H., Loukas, A. & Buck, A. H., 05 Aug 2020, In: International Journal for Parasitology. 50, 9, p. 621-622 2 p.Research output: Contribution to journal › Editorial
- 2019
The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets
Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Nov 2019, In: PLoS Neglected Tropical Diseases. 13, 11, 24 p., e0007693.Research output: Contribution to journal › Article › peer-review
Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs Drug Resist. 8 (2018) 559–570]
Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., 02 Jul 2019, In: International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 91 1 p.Research output: Contribution to journal › Article › peer-review