Prof Karl Hoffmann PhD

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Nov 2019, In : PLoS Neglected Tropical Diseases. 13, 11, e0007693.

Research output: Contribution to journal › Article

Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs Drug Resist. 8 (2018) 559–570]

Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., 02 Jul 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 91 1 p.

Research output: Contribution to journal › Article

Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Farias, L. P., Chalmers, I., Perally, S., Rofatto, H. K., Jackson, C. J., Brown, M., Khouri, M. I., Barbosa, M. M. F., Hensbergen, P. J., Hokke, C. H., Leite, L. C. C. & Hoffmann, K., 01 Jul 2019, In : International Journal for Parasitology. 49, 8, p. 593-599 7 p.

Research output: Contribution to journal › Article

The anti-mycobacterial activity of a diterpenoid-like molecule operates through nitrogen and amino acid starvation

Crusco, A., Alves Baptista, R., Bhowmick, S., Beckmann, M., Mur, L., Westwell, A. D. & Hoffmann, K., 25 Jun 2019, In : Frontiers in Microbiology. 10, 01444.

Research output: Contribution to journal › Article

Antischistosomal Properties of Sclareol and Its Heck-Coupled Derivatives: Design, Synthesis, Biological Evaluation and Untargeted Metabolomics

Crusco, A., Whiteland, H., Baptista, R., Forde-Thomas, J., Beckmann, M., Mur, L., Nash, R. J., Westwell, A. D. & Hoffmann, K., 28 May 2019, In : ACS Infectious Diseases.

Research output: Contribution to journal › Article

Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni

Wannaporn, I., Mann, V., Karinshak, S., Coghlan, A., Rinaldi, G., Sankaranarayanan, G., Chaidee, A., Tanno, T., Kumkhaek, C., Prangtaworn, P., Mentink-Kane, M. M., Cochran, C. J., Driguez, P., Holroyd, N., Tracey, A., Rodpai, R., Everts, B., Hokke, C. H., Hoffmann, K., Berriman, M. & 1 othersBrindley, P. J., 15 Jan 2019, In : eLife. 8, e41337.

Research output: Contribution to journal › Article

An Abeis procera - Derived tetracyclic triterpene containing a steroid-like core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni

Whiteland, H., Chakroborty, A., Forde-Thomas, J., Crusco, A., Cookson, A., Hollinshead, J., Fenn, C., Bartholomew, B., Holdsworth, P. A., Fisher, M., Nash, R. J. & Hoffmann, K., 01 Dec 2018, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 465-474 10 p.

Research output: Contribution to journal › Article

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., 01 Dec 2018, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 559-570 12 p.

Research output: Contribution to journal › Article

Corrigendum to ‘the anti-fecundity effect of 5-azacytidine (5-AzaC) on Schistosoma mansoni is linked to dis-regulated transcription, translation and stem cell activities’: [Int. J. Parasitol. Drugs and Drug Resist. 8 (2018) 213–222]

Geyer, K. K., Munshi, S. E., Vickers, M., Squance, M., Wilkinson, T., Berrar, D., Chaparro, C., Swain, M. & Hoffmann, K., 01 Dec 2018, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 493 1 p.

Research output: Contribution to journal › Article

Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Egesa, M., Lubyayi, L., Jones, F. M., van Diepen, A., Chalmers, I., Tukahebwa, E. M., Bagaya, B. S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Elliot, A. M., Yazdanbakhsh, M., Wilson, S. & Cose, S., 14 Oct 2018, In : Parasite Immunology. 40, 12, e12591.

Research output: Contribution to journal › Article