Dr Iain Chalmers PhD

Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation

Padalino, G., El-Sakkary, N., Liu, L. J., Liu, C., Harte, D. S. G., Barnes, R. E., Sayers, E., Forde-Thomas, J., Whiteland, H., Bassetto, M., Ferla, S., Johnson, G., Jones, A. T., Caffrey, C. R., Chalmers, I., Brancale, A. & Hoffmann, K., 15 Dec 2021, In: European Journal of Medicinal Chemistry. 226, 19 p., 113823.

Research output: Contribution to journal › Article › peer-review

Schistosoma mansoni venom allergen-like protein 6 (SmVAL6) maintains tegumental barrier function

Perally, S., Geyer, K. K., Farani, P. S. G., Chalmers, I., Fernandez Fuentes, N., Maskell, D. R., Hulme, B. J., Forde-Thomas, J., Phillips, D., Farias, L. P., Collins, J. J. & Hoffmann, K., 01 Mar 2021, In: International Journal for Parasitology. 51, 4, p. 251-261 11 p.

Research output: Contribution to journal › Article › peer-review

The repositioning of epigenetic probes/inhibitors identifies new anti-schistosomal lead compounds and chemotherapeutic targets

Whatley, K., Padalino, G., Whiteland, H., Geyer, K. K., Hulme, B. J., Chalmers, I., Forde-Thomas, J., Ferla, S., Brancale, A. & Hoffmann, K., 15 Nov 2019, In: PLoS Neglected Tropical Diseases. 13, 11, 24 p., e0007693.

Research output: Contribution to journal › Article › peer-review

Erratum to ‘Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni’ [IJP Drugs Drug Resist. 8 (2018) 559–570]

Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., 02 Jul 2019, In: International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 91 1 p.

Research output: Contribution to journal › Article › peer-review

Schistosoma mansoni venom allergen-like proteins: phylogenetic relationships, stage-specific transcription and tissue localization as predictors of immunological cross-reactivity

Farias, L. P., Chalmers, I., Perally, S., Rofatto, H. K., Jackson, C. J., Brown, M., Khouri, M. I., Barbosa, M. M. F., Hensbergen, P. J., Hokke, C. H., Leite, L. C. C. & Hoffmann, K., 01 Jul 2019, In: International Journal for Parasitology. 49, 8, p. 593-599 7 p.

Research output: Contribution to journal › Article › peer-review

Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni

Padalino, G., Ferla, S., Brancale, A., Chalmers, I. & Hoffmann, K., 31 Dec 2018, In: International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 559-570 12 p.

Research output: Contribution to journal › Article › peer-review

Antibody Responses to Schistosoma mansoni Schistosomula Antigens

Egesa, M., Lubyayi, L., Jones, F. M., van Diepen, A., Chalmers, I., Tukahebwa, E. M., Bagaya, B. S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Elliot, A. M., Yazdanbakhsh, M., Wilson, S. & Cose, S., 14 Oct 2018, In: Parasite Immunology. 40, 12, e12591.

Research output: Contribution to journal › Article › peer-review

S. mansoni Schistosomula Antigens Induce Th1/Proinflammatory Cytokine Responses

Egesa, M., Lubyayi, L., Tukahebwa, E. M., Bagaya, B. S., Chalmers, I., Wilson, S., Hokke, C. H., Hoffmann, K., Dunne, D. W., Yazdanbakhsh, M., Labuda, L. A. & Cose, S., 21 Sep 2018, In: Parasite Immunology. e12592.

Research output: Contribution to journal › Article › peer-review

The Biomphalaria glabrata DNA methylation machinery displays spatial tissue expression, is differentially active in distinct snail populations and is modulated by interactions with Schistosoma mansoni

Geyer, K., Niazi, U., Duval, D., Cosseau, C., Tomlinson, C., Chalmers, I., Swain, M., Cutress, D., Bickham-Wright, U., Munshi, S. E., Grunau, C., Yoshino, T. P. & Hoffmann, K., 16 May 2017, In: PLoS Neglected Tropical Diseases. 11, 5, 29 p., e0005246.

Research output: Contribution to journal › Article › peer-review

Whole genome analysis of a schistosomiasis-transmitting freshwater snail

Adema, C. M., Hillier, L. W., Jones, C. S., Loker, E. S., Knight, M., Minx, P., Oliveira, G., Raghavan, N., Shedlock, A., do Amaral, L. R., Arican-Goktas, H. D., Assis, J. G., Baba, E. H., Baron, O. L., Bayne, C. J., Bickham-Wright, U., Biggar, K. K., Blouin, M., Bonning, B. C., Botka, C. & 97 others, Bridger, J. M., Buckley, K. M., Buddenborg, S. K., Lima Caldeira, R., Carleton, J., Carvalho, O. S., Castillo, M. G., Chalmers, I., Christensens, M., Clifton, S., Cosseau, C., Coustau, C., Cripps, R. M., Cuesta-Astroz, Y., Cummins, S. F., Di Stephano, L., Dinguirard, N., Duval, D., Emrich, S., Feschotte, C., Feyereisen, R., Fitzgerald, P., Fronick, C., Fulton, L., Galinier, R., Gava, S. G., Geusz, M., Geyer, K. K., Giraldo-Calderón, G. I., de Souza Gomes, M., Gordy, M. A., Gourbal, B., Grunau, C., Hanington, P. C., Hoffmann, K., Hughes, D., Humphries, J., Jackson, D. J., Jannotti-Passos, L. K., De Jesus Jeremias, W., Jobling, S., Kamel, B., Kapusta, A., Kaur, S., Koene, J. M., Kohn, A. B., Lawson, D., Lawton, S. P., Liang, D., Limpanont, Y., Liu, S., Lockyer, A. E., Lovato, T. L., Ludolf, F., Magrini, V., Mcmanus, D. P., Medina, M., Misra, M., Mitta, G., Mkoji, G. M., Montague, M. J., Montelongo, C., Moroz, L. L., Munoz-Torres, M. C., Niazi, U., Noble, L. R., Oliveira, F. S., Pais, F. S., Papenfuss, A. T., Peace, R., Pena, J. J., Pila, E. A., Quelais, T., Raney, B. J., Rast, J. P., Rollinson, D., Rosse, I. C., Rotgans, B., Routledge, E. J., Ryan, K. M., Scholte, L. L. S., Storey, K. B., Swain, M., Tennessen, J. A., Tomlinson, C., Trujillo, D. L., Volpi, E. V., Walker, A. J., Wang, T., Wannaporn, I., Warren, W. C., Wu, X., Yoshino, T. P., Yusuf, M., Zhang, S., Zhao, M. & Wilson, R. K., 16 May 2017, In: Nature Communications. 8, p. 15451 15451 (2017).

Research output: Contribution to journal › Article › peer-review