Transcriptional repression by MYB3R proteins regulates plant organ growth

Awduron Sefydliadau
  • Kosuke Kobayashi(Awdur)
    Nagoya University
  • Toshiya Suzuki(Awdur)
    Nagoya University
  • eriko Iwata(Awdur)
    Nagoya University
  • Poyu Chen(Awdur)
    Nara Institute of Science and Technology
  • Misato Ohtani(Awdur)
    Nara Institute of Science and Technology
    RIKEN Center for Sustainable Resource Science
  • Takashi Ishida(Awdur)
    Kumamoto University
  • Hanako Hosoya(Awdur)
    Tokyo Gakugei University
  • Sabine Müller(Awdur)
    University of Tübingen
  • Tünde Leviczky(Awdur)
    Biological Research Centre, Szeged
  • Aladár Pettkó-Szandtner(Awdur)
    Biological Research Centre, Szeged
  • Zsuzsanna Darula(Awdur)
    Biological Research Centre, Szeged
  • Akitoshi Iwamoto(Awdur)
    Tokyo Gakugei University
  • Mika Nomoto(Awdur)
    Nagoya University
  • Yasuomi Tada(Awdur)
    Nagoya University
  • Tetsuya Higashiyama(Awdur)
    Nagoya University
  • Taku Demura(Awdur)
    RIKEN Center for Sustainable Resource Science
    Nara Institute of Science and Technology
  • John Doonan(Awdur)
  • Marie-Theres Hauser(Awdur)
    University of Natural Resources and Life Sciences, Vienna
  • Keiko Sugimoto(Awdur)
    RIKEN Center for Sustainable Resource Science
  • Masaaki Umeda(Awdur)
    Nara Institute of Science and Technology
  • Zoltán Magyar(Awdur)
    Biological Research Centre, Szeged
    University of London
  • László Bögre(Awdur)
    University of London
  • Masaki Ito(Awdur)
    Nagoya University
Math Erthygl
Iaith wreiddiolSaesneg
Tudalennau (o-i)1992-2007
CyfnodolynEMBO Journal
Cyfrol34
Rhif y cyfnodolyn15
Dyddiad ar-lein cynnar11 Meh 2015
Dangosyddion eitem ddigidol (DOIs)
StatwsCyhoeddwyd - 04 Awst 2015
Cysylltiadau
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Crynodeb

In multicellular organisms, temporal and spatial regulation of cell proliferation is central for generating organs with defined sizes and morphologies. For establishing and maintaining the post-mitotic quiescent state during cell differentiation, it is important to repress genes with mitotic functions. We found that three of the Arabidopsis MYB3R transcription factors synergistically maintain G2/M-specific genes repressed in post-mitotic cells and restrict the time window of mitotic gene expression in proliferating cells. The combined mutants of the three repressor-type MYB3R genes displayed long roots, enlarged leaves, embryos, and seeds. Genome-wide chromatin immunoprecipitation revealed that MYB3R3 binds to the promoters of G2/M-specific genes and to E2F target genes. MYB3R3 associates with the repressor-type E2F, E2FC, and the RETINOBLASTOMA RELATED proteins. In contrast, the activator MYB3R4 was in complex with E2FB in proliferating cells. With mass spectrometry and pairwise interaction assays, we identified some of the other conserved components of the multiprotein complexes, known as DREAM/dREAM in human and flies. In plants, these repressor complexes are important for periodic expression during cell cycle and to establish a post-mitotic quiescent state determining organ size

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