(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach

Awduron Sefydliadau
  • Celine Cosseau(Awdur)
    University Montpellier
  • Olaf Wolkenhauer(Awdur)
    Univeristy of Rostock
    Stellenbosch Institute for Advanced Study (STIAS)
  • Gilda Padalino(Awdur)
  • Kathrin Geyer(Awdur)
  • Karl Hoffmann(Awdur)
  • Christoph Grunau(Awdur)
    University Montpellier
Math Erthygl
Iaith wreiddiolSaesneg
Tudalennau (o-i)285-294
Nifer y tudalennau5
CyfnodolynTrends in Parasitology
Cyfrol33
Rhif y cyfnodolyn4
Dyddiad ar-lein cynnar28 Rhag 2016
Dangosyddion eitem ddigidol (DOIs)
StatwsCyhoeddwyd - 01 Ebr 2017
Cysylltiadau
Arddangos ystadegau lawrlwytho
Gweld graff cysylltiadau
Fformatau enwi

Crynodeb

The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success.